|
KMID : 1098420050130020075
|
|
Korean Journal of Medicinal Crop Science
2005 Volume.13 No. 2 p.75 ~ p.79
|
|
|
The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity
|
|
Zheng Ming-Shan
Jin Wen-Yi
Son Kun-Ho
Chang Hyun-Wook
Kim Hyun-Pyo
Bae Ki-Hwan
Kang Sam-Sik
|
|
|
Abstract
|
|
|
|
Five coumarins, psoralen (1), scopoletin (2), isoimperatorin (4), (+)-marmesin (5) and xanthotoxin (6), three chromones, cimifugin (3), hamaudol (7) and sec-O-glucosylhamaudol (10), one sterol, daucosterol (8) and one aliphatic alcohol, galactitol (9) were isolated from the root of Peucedanum japonicum. Their chemical structures were identified by the physicochemical and spectroscopic data by comparing literature values. Among them, compounds 9 and 10 were isolated for the first time from this plant. The anti-inflammatory effects of isolated compounds were examined on cyclooxygenase (COX), compounds 1, 2 and 7 showed inhibitory activity on COX-1 with IC_{50} values of 0.88, 0.27 and 0.30 mM, respectively. In the test for COX-2 activity, only compound 7 showed significant inhibitory activity with the IC_{50} value of 0.57 mM. The other compounds exhibited weak inhibitory or no inhibitory activity.
|
|
|
KEYWORD
|
|
|
Peucedanum japonicum, coumarins, chromones, anti-inflammatory, COX-1, COX-2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|